C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene.
نویسندگان
چکیده
Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grignard reagents to artemisitene provided C-16-derived artemisinin monomers, dimers, trimers, and tetramers whose antimalarial and cytotoxic activities have been evaluated.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of medicinal chemistry
دوره 44 26 شماره
صفحات -
تاریخ انتشار 2001